Can we save the Purchase enquire of multiple items with different suppliers ?

Yes,

A Purchase Enquiry is generated for multiple suppliers. The supplier offering the best price is chosen, and their details are transferred to a Purchase Order.

You can save a Purchase Enquiry for multiple items with different suppliers or for a single item with multiple suppliers.

Purchase Enquiries are typically utilized when purchasing items that are not part of regular procurement. In cases where no prior agreement exists with a specific supplier, a Purchase Enquiry is created to solicit price quotes from various suppliers.